|
KMID : 0616619970030020589
|
|
Journal of Soonchunhyang Medical College
1997 Volume.3 No. 2 p.589 ~ p.598
|
|
|
Effects of preoperative ketamine on serum interleukin-6 level and postoperative pain in Caesarean-section patients
|
|
|
|
|
Abstract
|
|
|
The inflammatory reaction to tissue damage during surgery may induce central sensitization followed by hyperalgesia. Previous studies suggest that central sensitization is related to N-methyl-D-aspartate (NMDA) receptor activation, which can be blocked with NMDA antagonist, ketamine. Thus, we compared the effect of preoperative intravenous and epidural low doses of ketamine with placebo on serum interleukin-6 (EL-6) level and postoperative pain.
ASA class I and H women scheduled for C-sections received intravenous ketamine 0.15 mg/kg(group 2) or placebo(group 1), or epidural ketamine(0.15 mg/kg) before the operation. IL-6 levels were measured before and during the operation, and 8, 24, and 48 hrs after the operation. Visual Analogue Scales(VAS) and Verbal Rating Scales(VRS) were measured at 8, 24, and 48 hrs after the operation.
Serum IL-6 levels at 8, 24, and 48 hrs after the operation were significantly lower in the intravenous ketamine and epidural ketamine groups than in the control group. VAS at 8 hrs and 48 hrs after the operation were significantly lower in the epidural ketamine group than in the control and intravenous ketamine groups.
In conclusion, in the preoperative intravenous and epidural administration of low doses(0.15 mg/kg) of ketamine, both are effective in reducing postoperative FL-6 levels. Epidural ketamine is more effective than intravenous ketamine in postoperative pain control.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|